Ontology highlight
ABSTRACT:
SUBMITTER: Fulton CR
PROVIDER: S-EPMC6562829 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Fulton Cathy R CR Zang Yong Y Desta Zeruesenay Z Rosenman Marc B MB Holmes Ann M AM Decker Brian S BS Zhang Yifei Y T Callaghan John J Pratt Victoria M VM Levy Kenneth D KD Gufford Brandon T BT Dexter Paul R PR Skaar Todd C TC Eadon Michael T MT
Pharmacogenomics 20190220 6
<b>Background:</b> Tramadol and codeine are metabolized by CYP2D6 and are subject to drug-gene and drug-drug interactions. <b>Methods:</b> This interim analysis examined prescribing behavior and efficacy in 102 individuals prescribed tramadol or codeine while receiving pharmaco-genotyping as part of the INGENIOUS trial (NCT02297126). <b>Results:</b> Within 60 days of receiving tramadol or codeine, clinicians more frequently prescribed an alternative opioid in ultrarapid and poor metabolizers (od ...[more]