Ontology highlight
ABSTRACT:
SUBMITTER: Davis BH
PROVIDER: S-EPMC6563016 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Davis Brittney H BH Dillon Chrisly C Cai Anping A Williams Iii Lance A LA Pamboukian Salpy V SV Limdi Nita A NA
Pharmacogenomics 20190501 7
Impaired response to P2Y<sub>12</sub> receptor antagonists, such as clopidogrel and prasugrel, can have devastating consequences for patients that require prolonged or indefinite therapy with these agents, including those with a left ventricular assist device (LVAD). While loss-of-function (LOF) alleles in <i>CYP2C19</i> have been elucidated as contributing to high on treatment platelet reactivity (HTPR) during clopidogrel therapy, genetic variations in the metabolic pathway of prasugrel have no ...[more]