Ontology highlight
ABSTRACT:
SUBMITTER: Kim KS
PROVIDER: S-EPMC6563032 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Kim Kwang Seock KS Jeong Dongjun D Sari Ita Novita IN Wijaya Yoseph Toni YT Jun Nayoung N Lee Sanghyun S Yang Ying-Gui YG Lee Sae Hwan SH Kwon Hyog Young HY
Cancers 20190527 5
Our current understanding of the role of microRNA 551b (miR551b) in the progression of colorectal cancer (CRC) remains limited. Here, studies using both ectopic expression of miR551b and miR551b mimics revealed that miR551b exerts a tumor suppressive effect in CRC cells. Specifically, miR551b was significantly downregulated in both patient-derived CRC tissues and CRC cell lines compared to normal tissues and non-cancer cell lines. Also, miR551b significantly inhibited the motility of CRC cells i ...[more]