Ontology highlight
ABSTRACT:
SUBMITTER: O'Hagan MP
PROVIDER: S-EPMC6563076 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
O'Hagan Michael P MP Haldar Susanta S Duchi Marta M Oliver Thomas A A TAA Mulholland Adrian J AJ Morales Juan C JC Galan M Carmen MC
Angewandte Chemie (International ed. in English) 20190220 13
The polymorphic nature of G-quadruplex (G4) DNA structures points to a range of potential applications in nanodevices and an opportunity to control G4 in biological settings. Light is an attractive means for the regulation of oligonucleotide structure as it can be delivered with high spatiotemporal precision. However, surprisingly little attention has been devoted towards the development of ligands for G4 that allow photoregulation of G4 folding. We report a novel G4-binding chemotype derived fr ...[more]