Epigenetic Reprogramming of TGF-? Signaling in Breast Cancer.
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ABSTRACT:
SUBMITTER: Suriyamurthy S
PROVIDER: S-EPMC6563130 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer.
Suriyamurthy Sudha S Baker David D Ten Dijke Peter P Iyengar Prasanna Vasudevan PV
Cancers 20190524 5
The Transforming Growth Factor-β (TGF-β) signaling pathway has a well-documented, context-dependent role in breast cancer development. In normal and premalignant cells, it acts as a tumor suppressor. By contrast, during the malignant phases of breast cancer progression, the TGF-β signaling pathway elicits tumor promoting effects particularly by driving the epithelial to mesenchymal transition (EMT), which enhances tumor cell migration, invasion and ultimately metastasis to distant organs. The mo ...[more]
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2017-06-03 | GSE99596 | GEO