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Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines.

ABSTRACT: Oncolytic viruses (OVs) are a form of immunotherapy that release tumor antigens in the context of highly immunogenic viral signals following tumor-targeted infection and destruction. Emerging preclinical and clinical evidence suggests that this in situ vaccine effect is critical for successful viro-immunotherapy. In this review, we discuss the application of OV as an infected cell vaccine (ICV) as one method of enhancing the potency and breadth of anti-tumoral immunity. We focus on understanding and manipulating the critical role of natural killer (NK) cells and their interactions with other immune cells to promote a clinical outcome. With a synergistic tumor killing and immune activating mechanism, ICVs represent a valuable new addition to the cancer fighting toolbox with the potential to treat malignant disease.

SUBMITTER: Niavarani SR

PROVIDER: S-EPMC6563237 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Treatment of Metastatic Disease through Natural Killer Cell Modulation by Infected Cell Vaccines.

Niavarani Seyedeh Raheleh SR Lawson Christine C Tai Lee-Hwa LH

Viruses 20190511 5

Oncolytic viruses (OVs) are a form of immunotherapy that release tumor antigens in the context of highly immunogenic viral signals following tumor-targeted infection and destruction. Emerging preclinical and clinical evidence suggests that this in situ vaccine effect is critical for successful viro-immunotherapy. In this review, we discuss the application of OV as an infected cell vaccine (ICV) as one method of enhancing the potency and breadth of anti-tumoral immunity. We focus on understanding ...[more]

PMID: 31083491

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