Ontology highlight
ABSTRACT:
SUBMITTER: Eveno T
PROVIDER: S-EPMC6563277 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Eveno Tanguy T Dirr Larissa L El-Deeb Ibrahim M IM Guillon Patrice P von Itzstein Mark M
Viruses 20190505 5
Human parainfluenza virus (hPIV) infections are a major cause of respiratory tract illnesses in children, with currently no available vaccine or drug treatment. The surface glycoprotein haemagglutinin-neuraminidase (HN) of hPIV has a central role in the viral life cycle, including neuraminic acid-recognising receptor binding activity (early stage) and receptor-destroying activity (late stage), which makes it an ideal target for antiviral drug disovery. In this study, we showed that targeting the ...[more]