Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC6563542 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Liu Hong H Wang Zhenzhen Z Bao Fangfang F Wang Chuan C Sun Lele L Zhang Huimin H Yu Gongqi G Mi Zihao Z Li Jianke J Li Lulu L Zhao Qing Q Yue Zhenhua Z Zhao Wei W Yu Wenjun W Cao Jing J Xiong Fei F Wang Yaru Y Chai Zemin Z Cheng Xiujun X Zhang Yuan Y Fu Fanghui F Lang Xiaoqiao X Wang Xiaoling X Irwanto Astrid A Krismawati Hana H Fu Xi'an X Sun Yonghu Y You Jiabao J Liu Jian J Pan Qing Q Chu Tongsheng T Liu Dianchang D Chen Shumin S Shen Jianping J Yan Liangbin L Zhang Guocheng G Liu Jianjun J Zhang Furen F Xiong Li L Yang Jun J Li Jinlan J Ke Wei W Li Ming M Ning Yong Y Xiong Junhao J Li Ming M Xiong Mingzhou M Yang Bin B Duan Qizhi Q Wang Hong H Li Wei W Kuang Yanfei Y Li Junhua J Wang Lamei L Cao Qiuyang Q Xiao Peng P Xiao Bangzhong B Zhang Lianhua L Lin Zhaoxing Z Wang Yaofei Y Shen Yunliang Y Yan Liying L Wu Wenbin W Zheng Hu H Zhan Xianfa X Li Wanghua W Shang Xiujian X Xu Yujun Y Liu Qiao Q
JAMA dermatology 20190601 6
<h4>Importance</h4>Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine. Although the HLA-B*13:01 polymorphism has been identified as the genetic determinant of DHS in the Chinese population, no studies to date have been done to evaluate whether prospective HLA-B*13:01 scre ...[more]