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Perfluorocarbon-Based 19 F MRI Nanoprobes for In Vivo Multicolor Imaging.


ABSTRACT: In vivo multicolor imaging is important for monitoring multiple biomolecular or cellular processes in biology. 19 F magnetic resonance imaging (MRI) is an emerging in vivo imaging technique because it can non-invasively visualize 19 F nuclei without endogenous background signals. Therefore, 19 F MRI probes capable of multicolor imaging are in high demand. Herein, we report five types of perfluorocarbon-encapsulated silica nanoparticles that show 19 F NMR peaks with different chemical shifts. Three of the nanoprobes, which show spectrally distinct 19 F NMR peaks with sufficient sensitivity, were selected for in vivo multicolor 19 F MRI. The nanoprobes exhibited 19 F MRI signals with three colors in a living mouse. Our in vivo multicolor system could be utilized for evaluating the effect of surface functional groups on the hepatic uptake in a mouse. This novel multicolor imaging technology will be a practical tool for elucidating in vivo biomolecular networks by 19 F MRI.

SUBMITTER: Akazawa K 

PROVIDER: S-EPMC6563715 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Perfluorocarbon-Based <sup>19</sup> F MRI Nanoprobes for In Vivo Multicolor Imaging.

Akazawa Kazuki K   Sugihara Fuminori F   Nakamura Tatsuya T   Matsushita Hisashi H   Mukai Hiroaki H   Akimoto Rena R   Minoshima Masafumi M   Mizukami Shin S   Kikuchi Kazuya K  

Angewandte Chemie (International ed. in English) 20181127 51


In vivo multicolor imaging is important for monitoring multiple biomolecular or cellular processes in biology. <sup>19</sup> F magnetic resonance imaging (MRI) is an emerging in vivo imaging technique because it can non-invasively visualize <sup>19</sup> F nuclei without endogenous background signals. Therefore, <sup>19</sup> F MRI probes capable of multicolor imaging are in high demand. Herein, we report five types of perfluorocarbon-encapsulated silica nanoparticles that show <sup>19</sup> F N  ...[more]

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