Ontology highlight
ABSTRACT:
SUBMITTER: Rees MG
PROVIDER: S-EPMC6563933 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Rees Matthew G MG Seashore-Ludlow Brinton B Clemons Paul A PA
Methods in molecular biology (Clifton, N.J.) 20190101
We recently pioneered several analyses of small-molecule sensitivity data collected from large-scale perturbation of hundreds of cancer cell lines with hundreds of small molecules, with cell viability measured as a readout of compound sensitivity. We performed these studies using cancer cell lines previously annotated with cellular, genomic, and basal gene-expression features. By combining small-molecule sensitivity data with these other datasets, we identified new candidate biomarkers of sensit ...[more]