Ontology highlight
ABSTRACT:
SUBMITTER: Yu Y
PROVIDER: S-EPMC6565366 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yu Yang Y Zhao Yanling Y Fan Yihui Y Chen Zhenghu Z Li Hui H Lu Jiaxiong J Guo Kevin K Woodfield Sarah E SE Vasudevan Sanjeev A SA Yang Jianhua J Nuchtern Jed G JG
Molecular cancer therapeutics 20190408 6
Neuroblastoma is the most common extracranial malignant solid tumor in children, and drug resistance is a major reason for poor outcomes. Elevated proteasome activity plays an important role in neuroblastoma tumor development and resistance to conventional chemotherapy. Ubiquitin-specific protease 14 (USP14), one of three deubiquitinases associated with the regulatory subunit of the proteasome, is emerging as a potential therapeutic target in multiple tumor types. However, the role of USP14 in n ...[more]