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Models of polymer physics for the architecture of the cell nucleus.

ABSTRACT: The depth and complexity of data now available on chromosome 3D architecture, derived by new technologies such as Hi-C, have triggered the development of models based on polymer physics to explain the observed patterns and the underlying molecular folding mechanisms. Here, we give an overview of some of the ideas and models from physics introduced to date, along with their progresses and limitations in the description of experimental data. In particular, we focus on the Strings&Binders and the Loop Extrusion model of chromatin architecture. This article is categorized under: Analytical and Computational Methods > Computational Methods.

SUBMITTER: Esposito A

PROVIDER: S-EPMC6565494 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Models of polymer physics for the architecture of the cell nucleus.

Esposito Andrea A Annunziatella Carlo C Bianco Simona S Chiariello Andrea M AM Fiorillo Luca L Nicodemi Mario M

Wiley interdisciplinary reviews. Systems biology and medicine 20181219 4

The depth and complexity of data now available on chromosome 3D architecture, derived by new technologies such as Hi-C, have triggered the development of models based on polymer physics to explain the observed patterns and the underlying molecular folding mechanisms. Here, we give an overview of some of the ideas and models from physics introduced to date, along with their progresses and limitations in the description of experimental data. In particular, we focus on the Strings&Binders and the L ...[more]

PMID: 30566285

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