Association of PTPN22 polymorphism and its correlation with Graves' disease susceptibility in Polish adult population-A preliminary study.

ABSTRACT:

Background

Susceptibility to Graves' disease (GD) is determined by various genetic factors; the gene encoding protein tyrosine phosphatase (PTPN22) may be one of those associated with higher risk of GD. The aim was to estimate the association of the PTPN22 gene polymorphism rs2476601:c.C>T (c.1858C>T) with the predisposition to GD within the adult north-eastern Polish population.

Methods

PTPN22 gene polymorphism was analyzed in individuals with clinical GD history (n = 166) and healthy subjects (n = 154). The presence of different variants of the investigated gene polymorphism was estimated using the DNA Sanger sequencing method.

Results

Patients with GD had a more frequent occurrence of the T gene allele of PTPN22 gene compared to the control group, however, it was n

SUBMITTER: Wawrusiewicz-Kurylonek N 

PROVIDER: S-EPMC6565548 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature