Ontology highlight
ABSTRACT:
SUBMITTER: Vijayakumar J
PROVIDER: S-EPMC6565635 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Vijayakumar Jeshlee J Perrois Charlène C Heim Marjorie M Bousset Luc L Alberti Simon S Besse Florence F
Nature communications 20190613 1
Prion-like domains (PLDs), defined by their low sequence complexity and intrinsic disorder, are present in hundreds of human proteins. Although gain-of-function mutations in the PLDs of neuronal RNA-binding proteins have been linked to neurodegenerative disease progression, the physiological role of PLDs and their range of molecular functions are still largely unknown. Here, we show that the PLD of Drosophila Imp, a conserved component of neuronal ribonucleoprotein (RNP) granules, is essential f ...[more]