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Precisely Endowing Colloidal Particles with Silica Branches.

ABSTRACT: A method to modify colloidal particles with silica rods in a water/n-pentanol system is reported here. Because of the interfacial tension between aqueous and n-pentanol phase, water which surrounds the colloidal particles de-wets into droplets during the deposition process of silica. As a result of unidirectional deposition, silica rods grow perpendicularly on the surface of the colloidal particles at the site of the smallest curvature where the water droplet has been de-wetted. By controlling the hydrolysis conditions, particles with certain number of branches or rambutan-like particles can be obtained. This approach opens a path towards the higher levels of colloidal complexity.

SUBMITTER: Zhao B

PROVIDER: S-EPMC6565735 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Precisely Endowing Colloidal Particles with Silica Branches.

Zhao Bin B Li Dongzhi D Long Yue Y Song Kai K

Scientific reports 20190613 1

A method to modify colloidal particles with silica rods in a water/n-pentanol system is reported here. Because of the interfacial tension between aqueous and n-pentanol phase, water which surrounds the colloidal particles de-wets into droplets during the deposition process of silica. As a result of unidirectional deposition, silica rods grow perpendicularly on the surface of the colloidal particles at the site of the smallest curvature where the water droplet has been de-wetted. By controlling t ...[more]

PMID: 31197202

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Project description:BackgroundMesoporous silica (MPS) nanoparticles (NPs), which have a unique pore structure and extremely large surface area and pore volume, have received much attention because of their biomedical application potential. Using MPS NPs for biomedical devices requires the verification of their biocompatibility because the surface area of NPs is one of the most important determinants of toxicity, including the cellular uptake and immune response. We have previously reported that the cytotoxicity and inflammation potential of MPS NPs have been shown to be lower than those of general amorphous colloidal silica (Col) NPs in macrophages, but the low cytotoxicity does not guarantee high biocompatibility in vivo. In this study, we compared the in vivo immunotoxicity of MPS and Col NPs in the mouse model to define the effects of pore structural conditions of silica NPs.Materials and methodsBoth MPS and Col NPs (2, 20, and 50 mg/kg/day) were intraperitoneally administered in female BALB/c mice for 4 weeks, and clinical toxicity, lymphocyte population, serum IgG/IgM levels, and histological changes were examined.ResultsThere was no overt sign of clinical toxicity in either MPS- or Col-treated mice. However, MPS NPs led to significant increases in liver and spleen weight and splenocyte proliferation. Mice treated with MPS NPs showed altered lymphocyte populations (CD3(+), CD45(+), CD4(+), and CD8(+)) in the spleen, increased serum IgG and IgM levels, and histological changes. Despite slight changes in lymphocyte populations in the spleen, Col NPs did not alter other immunological factors.ConclusionThe results indicate that in vivo exposure to MPS NPs caused more damage to systemic immunity than that of Col NPs through the dysregulation of the spleen. The results for in vivo data are inconsistent with those for in vitro data, which show lower cytotoxicity for MPS NPs. These results suggest the importance of verifying biocompatibility both in vitro and in vivo during the design of new nanomaterials.

Dataset Information

Precisely Endowing Colloidal Particles with Silica Branches.

Publications

Precisely Endowing Colloidal Particles with Silica Branches.

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