Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway.
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SUBMITTER: Do H
PROVIDER: S-EPMC6565748 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway.
Do Hackwon H Makthal Nishanth N VanderWal Arica R AR Saavedra Matthew Ojeda MO Olsen Randall J RJ Musser James M JM Kumaraswami Muthiah M
Nature communications 20190613 1
Bacteria control gene expression in concert with their population density by a process called quorum sensing, which is modulated by bacterial chemical signals and environmental factors. In the human pathogen Streptococcus pyogenes, production of secreted virulence factor SpeB is controlled by a quorum-sensing pathway and environmental pH. The quorum-sensing pathway consists of a secreted leaderless peptide signal (SIP), and its cognate receptor RopB. Here, we report that the SIP quorum-sensing p ...[more]
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