Developing a mouse model of acute encephalopathy using low-dose lipopolysaccharide injection and hyperthermia treatment.
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ABSTRACT: Impact statement
Acute encephalopathy (AE), mainly reported in East Asia, is classified into four categories based on clinical and neuropathological findings. Among them, AE caused by cytokine storm is known as the severest clinical entity that causes cerebral edema with poor prognosis. Because suitable and convenient model animal of AE had not been developed, the treatment of patients with AE is not established. In the present study, we established a simple and convenient protocol to mimic AE due to cytokine storm. Our model animal should be useful to elucidate the pathogenesis of AE.
SUBMITTER: Kurata H
PROVIDER: S-EPMC6567586 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Developing a mouse model of acute encephalopathy using low-dose lipopolysaccharide injection and hyperthermia treatment.
Kurata Hirofumi H Saito Kengo K Kawashima Fumiaki F Ikenari Takuya T Oguri Masayoshi M Saito Yoshiaki Y Maegaki Yoshihiro Y Mori Tetsuji T
Experimental biology and medicine (Maywood, N.J.) 20190502 9
<h4>Impact statement</h4>Acute encephalopathy (AE), mainly reported in East Asia, is classified into four categories based on clinical and neuropathological findings. Among them, AE caused by cytokine storm is known as the severest clinical entity that causes cerebral edema with poor prognosis. Because suitable and convenient model animal of AE had not been developed, the treatment of patients with AE is not established. In the present study, we established a simple and convenient protocol to mi ...[more]
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