Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis.
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ABSTRACT: Background
There have been a number of studies about seroprevalence of HEV among pregnant women in Africa. However, the finding of seroprevalence of HEV infection among pregnant women is variable and inconsistent. Therefore; this systematic review intended to provide the pooled seroprevalence of HEV among pregnant women in Africa.Methods
We searched, Pub Med, Science direct, African online journals and Google scholar electronic data bases and all available references until August 30, 2018. We included cross sectional studies and cohort studies. The search was further limited studies done in African pregnant women. Statistical analysis done by using Stata (version 11) software. The overall pooled prevalence of HEV presented by using the forest plot with 95% CI. The methodological qualities of included studies were assessed using Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instruments.Result
The pooled seroprevalence of HEV among pregnant women in Africa was 29.13% (95% CI 14.63-43.63). The highest seroprevalence was 84.3% in Egypt and the lowest 6.6% reported in Gabon. There was highest heterogeneity level where I2?=?99.7%; P?ConclusionThe seroprevalence of HEV among pregnant women in Africa is high. The seroprevalence of HEV among pregnant women differ with geographic location and assay method. Therefore, it is recommended to conduct further research on commercial ELISA kit sensitivity and specificity, molecular tests, incidence, morbidity and mortality and vertical transmission of HEV from mother to infant in Africa.Trial registration
CRD42018084963 .
SUBMITTER: Dagnew M
PROVIDER: S-EPMC6567642 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis.
Dagnew Mulat M Belachew Amare A Tiruneh Moges M Moges Feleke F
BMC infectious diseases 20190613 1
<h4>Background</h4>There have been a number of studies about seroprevalence of HEV among pregnant women in Africa. However, the finding of seroprevalence of HEV infection among pregnant women is variable and inconsistent. Therefore; this systematic review intended to provide the pooled seroprevalence of HEV among pregnant women in Africa.<h4>Methods</h4>We searched, Pub Med, Science direct, African online journals and Google scholar electronic data bases and all available references until August ...[more]
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