Current status and applications of genome-scale metabolic models.
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ABSTRACT:
SUBMITTER: Gu C
PROVIDER: S-EPMC6567666 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Current status and applications of genome-scale metabolic models.
Gu Changdai C Kim Gi Bae GB Kim Won Jun WJ Kim Hyun Uk HU Lee Sang Yup SY
Genome biology 20190613 1
Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction associations for entire metabolic genes in an organism, and can be simulated to predict metabolic fluxes for various systems-level metabolic studies. Since the first GEM for Haemophilus influenzae was reported in 1999, advances have been made to develop and simulate GEMs for an increasing number of organisms across bacteria, archaea, and eukarya. Here, we review current reconstructed GEMs and discuss their applic ...[more]
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