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Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles.


ABSTRACT: OBJECTIVES:To investigate the relationships between interferon alpha (IFN?) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distinct subpopulation of patients can be identified. METHODS:We recruited patients with at least 1 SARD clinical feature and at least 1 SARD-related autoantibody from two NHS Trusts in Greater Manchester. A 6-gene interferon-stimulated gene (ISG) score was calculated in all patients, and in a subgroup, a 30-gene ISG score was produced using NanoString. A digital Single Molecule Array (Simoa) was used to measure plasma IFN? protein. In an exploratory analysis, whole blood RNA sequencing was conducted in 12 patients followed by RT-qPCR confirmation of expression of 6 nucleic acid receptors (NARs) in the whole cohort. RESULTS:Sixty three of 164 (38%) patients had a positive ISG score. The 3 measures of IFN? all correlated strongly with each other (p?

SUBMITTER: Reynolds JA 

PROVIDER: S-EPMC6567906 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles.

Reynolds John A JA   Briggs Tracy A TA   Rice Gillian I GI   Darmalinggam Sathya S   Bondet Vincent V   Bruce Ellen E   Khan Mumtaz M   Haque Sahena S   Chinoy Hector H   Herrick Ariane L AL   McCarthy Eoghan M EM   Zeef Leo L   Hayes Andrew A   Duffy Darragh D   Parker Ben B   Bruce Ian N IN  

Arthritis research & therapy 20190614 1


<h4>Objectives</h4>To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distinct subpopulation of patients can be identified.<h4>Methods</h4>We recruited patients with at least 1 SARD clinical feature and at least 1 SARD-related autoantibody from two NHS Trusts in Greater Manchester. A 6-gene interferon-stimulated gene (ISG) score was calculated in  ...[more]

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