Ontology highlight
ABSTRACT:
SUBMITTER: Mnika K
PROVIDER: S-EPMC6568309 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Mnika Khuthala K Mazandu Gaston K GK Jonas Mario M Pule Gift D GD Chimusa Emile R ER Hanchard Neil A NA Wonkam Ambroise A
Frontiers in genetics 20190528
Hydroxyurea (HU) is clinically beneficial in sickle cell disease (SCD) through fetal hemoglobin (HbF) induction; however, the mechanism of HU is not yet fully elucidated. Selected miRNAs have been associated with HU-induced HbF production. We have investigated differential HU-induced global miRNA expression in peripheral blood of adult SCD patients in patients from Congo, living in South Africa. We found 22 of 798 miRNAs evaluated that were differentially expressed under HU treatment, with the m ...[more]