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Evaluating Patient Brain and Behavior Pathways to Caregiver Health in Neurodegenerative Diseases.


ABSTRACT: BACKGROUND:Caregivers of patients with neurodegenerative diseases are at heightened risk for serious health problems, but health differences between individual caregivers abound. AIMS:To determine whether atrophy in patient brains could be used to identify caregivers at heightened risk for health problems and which patient variables mediate this relationship. METHODS:In 162 patient-caregiver dyads, we assessed patient atrophy using structural MRI, caregiver health, and patient behavior and cognitive symptoms. RESULTS:Patient atrophy in the right insula and medial frontal gyrus was associated with worse caregiver health; this relationship was partially mediated by patient neuropsychiatric symptoms, and assessing atrophy in these regions improved predictions of poor caregiver health above and beyond patient behavioral symptoms. CONCLUSIONS:This study shows the value of patients' brain data in identifying caregivers at risk for becoming sick themselves.

SUBMITTER: Hua AY 

PROVIDER: S-EPMC6568322 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Evaluating Patient Brain and Behavior Pathways to Caregiver Health in Neurodegenerative Diseases.

Hua Alice Y AY   Wells Jenna L JL   Haase Claudia M CM   Chen Kuan-Hua KH   Rosen Howard J HJ   Miller Bruce L BL   Levenson Robert W RW  

Dementia and geriatric cognitive disorders 20190110 1-2


<h4>Background</h4>Caregivers of patients with neurodegenerative diseases are at heightened risk for serious health problems, but health differences between individual caregivers abound.<h4>Aims</h4>To determine whether atrophy in patient brains could be used to identify caregivers at heightened risk for health problems and which patient variables mediate this relationship.<h4>Methods</h4>In 162 patient-caregiver dyads, we assessed patient atrophy using structural MRI, caregiver health, and pati  ...[more]

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