Ontology highlight
ABSTRACT:
SUBMITTER: Azkanaz M
PROVIDER: S-EPMC6570483 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
eLife 20190614
Maintenance of epigenetic modifiers is of utmost importance to preserve the epigenome and consequently appropriate cellular functioning. Here, we analyzed Polycomb group protein (PcG) complex integrity in response to heat shock (HS). Upon HS, various Polycomb Repressive Complex (PRC)1 and PRC2 subunits, including CBX proteins, but also other chromatin regulators, are found to accumulate in the nucleolus. In parallel, binding of PRC1/2 to target genes is strongly reduced, coinciding with a dramat ...[more]