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Acute Coronary Syndrome Symptom Clusters: Illustration of Results Using Multiple Statistical Methods.


ABSTRACT: Researchers have employed various methods to identify symptom clusters in cardiovascular conditions, without identifying rationale. Here, we test clustering techniques and outcomes using a data set from patients with acute coronary syndrome. A total of 474 patients who presented to emergency departments in five United States regions were enrolled. Symptoms were assessed within 15 min of presentation using the validated 13-item ACS Symptom Checklist. Three variable-centered approaches resulted in four-factor solutions. Two of three person-centered approaches resulted in three-cluster solutions. K-means cluster analysis revealed a six-cluster solution but was reduced to three clusters following cluster plot analysis. The number of symptoms and patient characteristics varied within clusters. Based on our findings, we recommend using (a) a variable-centered approach if the research is exploratory, (b) a confirmatory factor analysis if there is a hypothesis about symptom clusters, and (c) a person-centered approach if the aim is to cluster symptoms by individual groups.

SUBMITTER: Ryan CJ 

PROVIDER: S-EPMC6570558 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Acute Coronary Syndrome Symptom Clusters: Illustration of Results Using Multiple Statistical Methods.

Ryan Catherine J CJ   Vuckovic Karen M KM   Finnegan Lorna L   Park Chang G CG   Zimmerman Lani L   Pozehl Bunny B   Schulz Paula P   Barnason Susan S   DeVon Holli A HA  

Western journal of nursing research 20190122 7


Researchers have employed various methods to identify symptom clusters in cardiovascular conditions, without identifying rationale. Here, we test clustering techniques and outcomes using a data set from patients with acute coronary syndrome. A total of 474 patients who presented to emergency departments in five United States regions were enrolled. Symptoms were assessed within 15 min of presentation using the validated 13-item ACS Symptom Checklist. Three variable-centered approaches resulted in  ...[more]

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