Ontology highlight
ABSTRACT:
SUBMITTER: Perez DR
PROVIDER: S-EPMC6571072 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Pharmacology & therapeutics 20190318
Clioquinol, one of the first mass-produced drugs, was considered safe and efficacious for many years. It was used as an antifungal and an antiprotozoal drug until it was linked to an outbreak of subacute myelo-optic neuropathy (SMON), a debilitating disease almost exclusively confined to Japan. Today, new information regarding clioquinol targets and its mechanism of action, as well as genetic variation (SNPs) in efflux transporters in the Japanese population, provide a unique interpretation of t ...[more]