IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population.

ABSTRACT: The study was performed to investigate the genetic associations of IGF-1 polymorphisms rs35767, rs5742714, and rs972936 with susceptibility to osteonecrosis of the femoral head (ONFH) among Chinese Han population.Totally, 101 ONFH patients and 128 healthy controls were enrolled. Hardy-Weinberg equilibrium (HWE) was detected with chi-square test in control group. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to estimate the relationship between IGF-1 polymorphisms and ONFH risk. Besides, hyplotype analysis was performed to examine linkage disequilibrium between the studied polymorphisms.Genotype AA and allele A of polymorphism rs35767 were more frequent in control group, and offered protection for ONFH onset (AA: OR?=?0.382, 95% CI?=?0.158-0.923; A: OR?=?0.650, 95% CI?=?0.442-0.956). Furthermore, the negative relationship was also observed between ONFH risk and polymorphism rs5742714 under the comparisons CG vs CC, and G vs C (OR?=?0.395, 95%CI?=?0.199-0.787; OR?=?0.346, 95%CI?=?0.191-0.627). While the polymorphism rs972936 significantly enhanced the disease risk (CT vs CC: OR?=?2.434, 95% CI?=?1.184-5.003; TT vs CC: OR?=?2.497, 95% CI?=?1.040-5.990). Furthermore, haplotype analysis demonstrated that C-T (rs5742714-rs972936) could increase ONFH risk (OR?=?2.177, 95% CI?=?1.444-3.283), while G-T might be a protective factor for ONFH (OR?=?0.472, 95% CI?=?0.254-0.878).IGF-1 polymorphisms rs35767, rs5742714, and rs972936 show significant association with ONFH risk.

SUBMITTER: Wang J 

PROVIDER: S-EPMC6571255 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature