Dataset Information

Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting.

Methods

We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding protein (Gal-3bp) for post-AMI risk stratification in a large, consecutive population of AMI patients. The primary outcomes were: Recurrent angina/AMI and all-cause mortality at 12 months after the index event.

Results

In total, 469 patients were included. The median Gal-3bp was 9.1 ?g/mL (IQR 5.8-13.5 ?g/mL), while median Gal-3 was 9.8 ng/mL (IQR 7.8-12.8 ng/mL). During the 12 month follow-up, 34 patients died and 41 had angina pectoris/reinfarction. Gal-3 was associated with all-cause mortality, while Gal-3bp correlated with the risk of angina/myocardial infarction even when corrected for other significant covariates. The final multivariable model for mortality prediction included patients' age, left ventricular ejection fraction (LVEF), Gal-3, and renal function. The ROC curve estimated for this model has an area under the curve (AUC) of 0.84 (95%CI 0.78-0.9), which was similar to the area under the ROC curve obtained using the GRACE score 1-year mortality.

Conclusions

The integrated assessment of Gal-3 and Gal-3bp could be helpful in risk stratification after AMI.

SUBMITTER: Gagno G

PROVIDER: S-EPMC6571589 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction.

Gagno Giulia G Padoan Laura L Stenner Elisabetta E Beleù Alessandro A Ziberna Fabiana F Hiche Cristina C Paldino Alessia A Barbati Giulia G Biolo Gianni G Fiotti Nicola N Not Tarcisio T Beltrami Antonio Paolo AP Sinagra Gianfranco G Aleksova Aneta A

Journal of clinical medicine 20190426 5

<h4>Background</h4>Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting.<h4>Methods</h4>We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding protein (Gal-3bp) for post-AMI risk stratification in a large, consecutive population of AMI patients. The primary outcomes were: Recu ...[more]

PMID: 31035456

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Dataset Information

Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction.

Background

Methods

Results

Conclusions

Publications

Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction.

Similar Datasets

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