Ontology highlight
ABSTRACT:
SUBMITTER: Goto R
PROVIDER: S-EPMC6571682 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Goto Rieko R Kondo Tatsuya T Ono Kaoru K Kitano Sayaka S Miyakawa Nobukazu N Watanabe Takuro T Sakaguchi Masaji M Sato Miki M Igata Motoyuki M Kawashima Junji J Motoshima Hiroyuki H Matsumura Takeshi T Shimoda Seiya S Araki Eiichi E
Journal of clinical medicine 20190514 5
Because the renin-angiotensin-aldosterone system influences glucose homeostasis, the mineralocorticoid receptor (MR) signal in pancreatic islets may regulate insulin response upon glucose load. Glucagon-like peptide-1 (GLP-1) production is stimulated by interleukin-6 (IL-6) in pancreatic α-cells. To determine how glucose homeostasis is regulated by interactions of MR, IL-6 and GLP-1 in islets, we performed glucose tolerance and histological analysis of islets in primary aldosteronism (PA) model ...[more]