Dataset Information

Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene.

ABSTRACT: Elevated serum urate (sUA) concentrations have been associated with an increased risk of hypertension. We aimed to examine the association of sUA concentration on the risk of hypertension in pre- and post-menopausal women and investigated the association between the polymorphism of the xanthine dehydrogenase gene and the risk of hypertension. Among 7294 women, 1415 premenopausal and 5879 postmenopausal women were recruited. Anthropometric parameters as risk factors of hypertension were identify by logistic regression models. In addition, we investigated an association between xanthine dehydrogenase gene and sUA and their combined associations on the risk of hypertension. Body mass index (BMI) and waist circumference (WC) were significantly increased in accordance to the increase of sUA levels (p < 0.001). Multivariate logistic regression analysis showed postmenopausal women with a high sUA and high BMI were 3.18 times more likely to have hypertension than in those with normal and lower sUA (Odds ratio: 3.18, 95% confidence interval: 2.54-3.96). Postmenopausal women with a high WC were 1.62 times more likely to have hypertension than in those with normal and lower sUA. Subjects with the AG genotype of rs206860 was found to be at lower risk of hypertension (odd ratio: 0.287, 95% confidence interval: 0.091-0.905, p = 0.033). This cross-sectional study indicated a high sUA is associated with a higher risk of hypertension in postmenopausal women. Further well-designed prospective studies in other populations are warranted to validate our results.

SUBMITTER: Lee JH

PROVIDER: S-EPMC6571698 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene.

Lee Jong-Han JH Go Tae Hwa TH Lee San-Hui SH Kim Juwon J Huh Ji Hye JH Kim Jang Young JY Kang Dae Ryong DR Jeong Seongmun S Koh Sang-Baek SB Choi Jung Ran JR

Journal of clinical medicine 20190523 5

Elevated serum urate (sUA) concentrations have been associated with an increased risk of hypertension. We aimed to examine the association of sUA concentration on the risk of hypertension in pre- and post-menopausal women and investigated the association between the polymorphism of the xanthine dehydrogenase gene and the risk of hypertension. Among 7294 women, 1415 premenopausal and 5879 postmenopausal women were recruited. Anthropometric parameters as risk factors of hypertension were identify ...[more]

PMID: 31126092

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Dataset Information

Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene.

Publications

Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene.

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