Dataset Information

Maternal smoking during pregnancy and offspring body composition in adulthood: Results from two birth cohort studies.

ABSTRACT:

Objective

To evaluate the association of maternal smoking during pregnancy with offspring body composition in adulthood and explore the causality of this association.

Design

Birth cohort.

Setting

Population-based study in Pelotas, Brazil.

Participants

All newborn infants in the city's hospitals were enrolled in 1982 and 1993. At a mean age of 30.2 and 22.6 years, the 1982 and 1993 cohorts, respectively, followed the subjects and 7222 subjects were evaluated.

Primary outcome measures

Body mass index (BMI), fat mass index, android to gynoid fat ratio, waist circumference, waist to height ratio, lean mass index and height.

Results

Prevalence of maternal smoking during pregnancy was 35.1% and 32.6%, in 1982 and 1993 cohorts, respectively. Offspring of smoking mothers showed higher mean BMI (?: 0.84; 95%?CI: 0.55 to 1.12?kg/m²), fat mass index (?: 0.44; 95%?CI: 0.23 to 0.64?kg/m²), android to gynoid fat ratio (?: 0.016; 95%?CI: 0.010 to 0.023), waist circumference (?: 1.74; 95%?CI: 1.15 to 2.33?cm), waist to height ratio (?: 0.013; 95%?CI: 0.010 to 0.017) and lean mass index (?: 0.33; 95%?CI: 0.24 to 0.42?kg/m²), whereas height was lower (?: -0.95; -1.26 to -0.65). Weight gain in the first 2?years captured most of the association of maternal smoking with BMI (96.2%), waist circumference (86.1%) and fat mass index (71.7%).

Conclusions

Maternal smoking in pregnancy was associated with offspring body composition measures in adulthood.

SUBMITTER: da Silva Magalhaes EI

PROVIDER: S-EPMC6575638 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Maternal smoking during pregnancy and offspring body composition in adulthood: Results from two birth cohort studies.

da Silva Magalhães Elma Izze EI Peixoto Lima Natália N Baptista Menezes Ana Maria AM Gonçalves Helen H Wehrmeister Fernando C FC Formoso Assunção MariaCecília M Lessa Horta Bernardo B

BMJ open 20190612 6

<h4>Objective</h4>To evaluate the association of maternal smoking during pregnancy with offspring body composition in adulthood and explore the causality of this association.<h4>Design</h4>Birth cohort.<h4>Setting</h4>Population-based study in Pelotas, Brazil.<h4>Participants</h4>All newborn infants in the city's hospitals were enrolled in 1982 and 1993. At a mean age of 30.2 and 22.6 years, the 1982 and 1993 cohorts, respectively, followed the subjects and 7222 subjects were evaluated.<h4>Prima ...[more]

PMID: 31196896

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Project description:BACKGROUND:Consistent evidence of an influence of maternal dietary intake during pregnancy on infant body size and composition in human populations is lacking, despite robust evidence in animal models. OBJECTIVE:We sought to evaluate the influence of maternal macronutrient intake and balance during pregnancy on neonatal body size and composition, including fat mass and fat-free mass. STUDY DESIGN:The analysis was conducted among 1040 mother-offspring pairs enrolled in the prospective prebirth observational cohort: the Healthy Start Study. Diet during pregnancy was collected using repeated 24-hour dietary recalls (up to 8). Direct measures of body composition were obtained using air displacement plethysmography. The National Cancer Institute measurement error model was used to estimate usual dietary intake during pregnancy. Multivariable partition (nonisocaloric) and nutrient density (isocaloric) linear regression models were used to test the associations between maternal dietary intake and neonatal body composition. RESULTS:The median macronutrient composition during pregnancy was 32.2% from fat, 15.0% from protein, and 47.8% from carbohydrates. In the partition multivariate regression model, individual macronutrient intake values were not associated with birthweight or fat-free mass, but were associated with fat mass. Respectively, 418 kJ increases in total fat, saturated fat, unsaturated fat, and total carbohydrates were associated with 4.2-g (P = .03), 11.1-g (P = .003), 5.9-g (P = .04), and 2.9-g (P = .02) increases in neonatal fat mass, independent of prepregnancy body mass index. In the nutrient density multivariate regression model, macronutrient balance was not associated with fat mass, fat-free mass, or birthweight after adjustment for prepregnancy body mass index. CONCLUSION:Neonatal adiposity, but not birthweight, is independently associated with increased maternal intake of total fat, saturated fat, unsaturated fat, and total carbohydrates, but not protein, suggesting that most forms of increased caloric intake contribute to fetal fat accretion.

Project description:ObjectiveTo examine the association of maternal hypertensive disorder of pregnancy (HDP) with overall and cause specific mortality in offspring from birth to young adulthood.DesignNationwide population based cohort study.SettingDanish national health registers.ParticipantsAll 2 437 718 individuals live born in Denmark, 1978-2018, with follow-up from date of birth until date of death, emigration, or 31 December 2018, whichever came first.Main outcome measuresThe primary outcome was all cause mortality. Secondary outcomes were 13 specific causes of death in offspring from birth to young adulthood (age 41 years). Cox regression was used to assess the association, taking into consideration several potential confounders. The role of timing of onset and severity of pre-eclampsia, maternal history of diabetes, and maternal education were also studied.Results102 095 mothers had HDP: 67 683 with pre-eclampsia, 679 with eclampsia, and 33 733 with hypertension. During follow-up to 41 years (median 19.4 (interquartile range 9.7-28.7) years), deaths occurred in 781 (58.94 per 100 000 person years) offspring born to mothers with pre-eclampsia, 17 (133.73 per 100 000 person years) born to mothers with eclampsia, 223 (44.38 per 100 000 person years) born to mothers with hypertension, and 19 119 (41.99 per 100 000 person years) born to mothers with no HDP. The difference in cumulative incidence in overall mortality between cohorts exposed and unexposed to maternal HDP was 0.37% (95% confidence interval 0.11% to 0.64%), and the population attributable fraction for maternal HDP was estimated as 1.09% (95% confidence interval 0.77% to 1.41%). Maternal HDP was associated with a 26% (hazard ratio 1.26, 95% confidence interval 1.18 to 1.34) higher risk of all cause mortality in offspring. The corresponding estimates for maternal pre-eclampsia, eclampsia, and hypertension were 1.29 (1.20 to 1.38), 2.88 (1.79 to 4.63), and 1.12 (0.98 to 1.28). Increased risks were also observed for several cause specific mortalities, such as deaths from conditions originating in the perinatal period (2.04, 1.81 to 2.30), cardiovascular diseases (1.52, 1.08 to 2.13), digestive system diseases (2.09, 1.27 to 3.43), and endocrine, nutritional, and metabolic diseases (1.56, 1.08 to 2.27). The increased risks were more pronounced among offspring of mothers with early onset and severe pre-eclampsia (6.06, 5.35 to 6.86) or with both HDP and diabetes history (1.57, 1.16 to 2.14) or HDP and low education level (1.49, 1.34 to 1.66).ConclusionMaternal HDP, particularly eclampsia and severe pre-eclampsia, is associated with increased risks of overall mortality and various cause specific mortalities in offspring from birth to young adulthood.

Dataset Information

Maternal smoking during pregnancy and offspring body composition in adulthood: Results from two birth cohort studies.

Objective

Design

Setting

Participants

Primary outcome measures

Results

Conclusions

Publications

Maternal smoking during pregnancy and offspring body composition in adulthood: Results from two birth cohort studies.

Similar Datasets

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