Ontology highlight
ABSTRACT:
SUBMITTER: Pastore N
PROVIDER: S-EPMC6576167 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Pastore Nunzia N Vainshtein Anna A Herz Niculin J NJ Huynh Tuong T Brunetti Lorenzo L Klisch Tiemo J TJ Mutarelli Margherita M Annunziata Patrizia P Kinouchi Kenichiro K Brunetti-Pierri Nicola N Sassone-Corsi Paolo P Ballabio Andrea A
The EMBO journal 20190524 12
Autophagy and energy metabolism are known to follow a circadian pattern. However, it is unclear whether autophagy and the circadian clock are coordinated by common control mechanisms. Here, we show that the oscillation of autophagy genes is dependent on the nutrient-sensitive activation of TFEB and TFE3, key regulators of autophagy, lysosomal biogenesis, and cell homeostasis. TFEB and TFE3 display a circadian activation over the 24-h cycle and are responsible for the rhythmic induction of genes ...[more]