Ontology highlight
ABSTRACT:
SUBMITTER: Relling MV
PROVIDER: S-EPMC6576267 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20190120 5
Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmacologic effects of thiopurines. Loss-of-function alleles in the NUDT15 gene are common in Asians and Hispanics and reduce the degradation of active thiopurine nucleotide metabolites, also predisposing to myelosuppression. We provide recommendations for adjusting starting doses of azathioprine, merca ...[more]