Two alternative promoters direct neuron-specific expression of the rat microtubule-associated protein 1B gene.

ABSTRACT: Microtubule-associated protein 1B (MAP1B) is a major constituent of the neuronal cytoskeleton that is expressed at high levels during early brain development and plays a role in axonal growth and neuronal plasticity. Previous studies suggested that the regulation of its gene expression is primarily at the transcriptional level. Thus, the characterization of the promoter region should help to define regulatory elements that control neuron-specific and developmental expression of the MAP1B gene. We have isolated genomic clones containing up to 11 kb of the upstream region of the rat MAP1B gene, sequenced approximately 1.8 kb upstream from the translation start codon, and identified several consensus sequences. These sequences include a consensus element common to several neuronal genes, a TC

SUBMITTER: Liu D 

PROVIDER: S-EPMC6579306 | biostudies-literature | 1996 Aug

REPOSITORIES: biostudies-literature