Ontology highlight
ABSTRACT:
SUBMITTER: Hunziker M
PROVIDER: S-EPMC6579516 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Hunziker Mirjam M Barandun Jonas J Buzovetsky Olga O Steckler Caitlin C Molina Henrik H Klinge Sebastian S
eLife 20190617
Eukaryotic ribosome biogenesis is initiated with the transcription of pre-ribosomal RNA at the 5' external transcribed spacer, which directs the early association of assembly factors but is absent from the mature ribosome. The subsequent co-transcriptional association of ribosome assembly factors with pre-ribosomal RNA results in the formation of the small subunit processome. Here we show that stable rRNA domains of the small ribosomal subunit can independently recruit their own biogenesis facto ...[more]