Ontology highlight
ABSTRACT:
SUBMITTER: Abebayehu D
PROVIDER: S-EPMC6579658 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Cellular immunology 20190412
Mast cells have functional plasticity affected by their tissue microenvironment, which greatly impacts their inflammatory responses. Because lactic acid (LA) is abundant in inflamed tissues and tumors, we investigated how it affects mast cell function. Using IgE-mediated activation as a model system, we found that LA suppressed inflammatory cytokine production and degranulation in mouse peritoneal mast cells, data that were confirmed with human skin mast cells. In mouse peritoneal mast cells, LA ...[more]