A Prospective Study of Circulating Tumor DNA to Guide Matched Targeted Therapy in Lung Cancers.
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ABSTRACT:
SUBMITTER: Sabari JK
PROVIDER: S-EPMC6579739 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
A Prospective Study of Circulating Tumor DNA to Guide Matched Targeted Therapy in Lung Cancers.
Sabari Joshua K JK Offin Michael M Stephens Dennis D Ni Andy A Lee Adrian A Pavlakis Nick N Clarke Stephen S Diakos Connie I CI Datta Sutirtha S Tandon Nidhi N Martinez Andres A Myers Mackenzie L ML Makhnin Alex A Leger Ysleni Y Yu Helena A HA Paik Paul K PK Chaft Jamie E JE Kris Mark G MG Jeon Jeong O JO Borsu Laetitia A LA Ladanyi Marc M Arcila Maria E ME Hernandez Jennifer J Henderson Samantha S Shaffer Tristan T Garg Kavita K DiPasquo Dan D Raymond Christopher K CK Lim Lee P LP Li Mark M Hellmann Matthew D MD Drilon Alexander A Riely Gregory J GJ Rusch Valerie W VW Jones David R DR Rimner Andreas A Rudin Charles M CM Isbell James M JM Li Bob T BT
Journal of the National Cancer Institute 20190601 6
<h4>Background</h4>Liquid biopsy for plasma circulating tumor DNA (ctDNA) next-generation sequencing (NGS) is commercially available and increasingly adopted in clinical practice despite a paucity of prospective data to support its use.<h4>Methods</h4>Patients with advanced lung cancers who had no known oncogenic driver or developed resistance to current targeted therapy (n = 210) underwent plasma NGS, targeting 21 genes. A subset of patients had concurrent tissue NGS testing using a 468-gene pa ...[more]
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