Dataset Information

Novel de novo frameshift variant in the ASXL3 gene in a child with microcephaly and global developmental delay.

ABSTRACT: De novo sequence variants, including truncating and splicing variants, in the additional sex?combs like 3 gene (ASXL3) have been described as the cause of Bainbridge?Ropers syndrome (BRS). This pathology is characterized by delayed psychomotor development, severe intellectual disability, growth delay, hypotonia and facial dimorphism. The present study reports a case of a girl (born in 2013) with severe global developmental delay, central hypotonia, microcephaly and poor speech. The proband was examined using a multi?step molecular diagnostics algorithm, including karyotype and array?comparative genomic hybridization analysis, with negative results. Therefore, the proband and her unaffected parents were enrolled for a pilot study using targeted next?generation sequencing technology (NGS) with gene panel ClearSeq Inherited DiseaseXT and subsequent validation by Sanger sequencing. A novel de novo heterozygous frameshift variant in the ASXL3 gene (c.3006delT, p.R1004Efs*21), predicted to result in a premature termination codon, was identified. In conclusion, the present study demonstrated that targeted NGS using a suitable, gene?rich panel may provide a conclusive molecular genetics diagnosis in children with severe global developmental delays.

SUBMITTER: Wayhelova M

PROVIDER: S-EPMC6579994 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Novel de novo frameshift variant in the ASXL3 gene in a child with microcephaly and global developmental delay.

Wayhelova Marketa M Oppelt Jan J Smetana Jan J Hladilkova Eva E Filkova Hana H Makaturova Eva E Nikolova Petra P Beharka Rastislav R Gaillyova Renata R Kuglik Petr P

Molecular medicine reports 20190527 1

De novo sequence variants, including truncating and splicing variants, in the additional sex‑combs like 3 gene (ASXL3) have been described as the cause of Bainbridge‑Ropers syndrome (BRS). This pathology is characterized by delayed psychomotor development, severe intellectual disability, growth delay, hypotonia and facial dimorphism. The present study reports a case of a girl (born in 2013) with severe global developmental delay, central hypotonia, microcephaly and poor speech. The proband was e ...[more]

PMID: 31180560

Dataset Information

Novel de novo frameshift variant in the ASXL3 gene in a child with microcephaly and global developmental delay.

Publications

Novel de novo frameshift variant in the ASXL3 gene in a child with microcephaly and global developmental delay.

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