Dataset Information

Chain-Shortened Myostatin Inhibitory Peptides Improve Grip Strength in Mice.

ABSTRACT: Inhibition of myostatin is a promising strategy for treatment of muscle atrophic disorders. We had already identified a 23-mer peptide (1) as a synthetic myostatin inhibitor, and structure-activity relationship studies with 1 afforded a potent 22-mer peptide derivative (3). Herein, we report the shortest myostatin inhibitory peptide so far. Among chain-shortened 16-mer peptidic inhibitors derived from the C-terminal region of 3, peptide inhibitor 8a with ?-sheet propensity was twice as potent as 22-mer inhibitor 3 and significantly increased not only muscle mass but also hind limb grip strength in Duchenne muscular dystrophic model mice. These results suggest that 8a is a promising platform for drug development treating muscle atrophic disorders.

SUBMITTER: Takayama K

PROVIDER: S-EPMC6580550 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Chain-Shortened Myostatin Inhibitory Peptides Improve Grip Strength in Mice.

Takayama Kentaro K Asari Tomo T Saitoh Mariko M Nirasawa Kei K Sasaki Eri E Roppongi Yoshimi Y Nakamura Akari A Saga Yusuke Y Shimada Takahiro T Ikeyama Hiroaki H Taguchi Akihiro A Taniguchi Atsuhiko A Negishi Yoichi Y Hayashi Yoshio Y

ACS medicinal chemistry letters 20190528 6

Inhibition of myostatin is a promising strategy for treatment of muscle atrophic disorders. We had already identified a 23-mer peptide (1) as a synthetic myostatin inhibitor, and structure-activity relationship studies with 1 afforded a potent 22-mer peptide derivative (3). Herein, we report the shortest myostatin inhibitory peptide so far. Among chain-shortened 16-mer peptidic inhibitors derived from the C-terminal region of 3, peptide inhibitor 8a with β-shee ...[more]

PMID: 31223459

Similar Datasets

Project description:BackgroundEvidence for non-pharmacological interventions in hand osteoarthritis is promising but still scarce. Combined interventions are most likely to best cover the clinical needs of patients with hand osteoarthritis (OA). The aim of this study was to evaluate the effect of a combined, interdisciplinary intervention feasible in both primary and specialist care compared to routine care plus placebo in patients with hand OA.MethodsThis was a randomised, controlled 2-month trial with a blinded assessor. In the combined-intervention group, rheumatology-trained health professionals from different disciplines delivered a one-session individual intervention with detailed information on functioning, activities of daily living, physical activity, nutrition, assistive devices, instructions on pain management and exercises. Telephone follow up was performed after 4 weeks. The primary outcome was grip strength after 8 weeks. Secondary outcomes were self-reported pain, satisfaction with treatment, health status, two of the Jebsen-Taylor Hand Function subtests and the total score of the Australian/Canadian Hand Osteoarthritis Index (AUSCAN). Statistical significance was calculated by Student's t test or the Mann-Whitney U test depending on data distribution. Binominal logistic regression models were fitted, with the primary outcome being the dependent and the group allocation being the independent variable.ResultsThere were 151 participating patients (74 in the combined-intervention and 77 in the routine-care-plus-placebo group) with 2-month follow-up attendance of 84% (n = 128). Grip strength significantly increased in the combined-intervention group and decreased in the routine-care group (dominant hand, mean 0.03 bar (SD 0.11) versus - 0.03 (SD 0.13), p value = 0.001, baseline corrected values) after 8 weeks.ConclusionThe combined one-session individual intervention significantly improved grip strength and self-reported satisfaction with treatment in patients with hand OA. It can be delivered by different rheumatology-trained health professionals and is thus also feasible in primary care.Trial registrationISRCTN registry, ISRCTN62513257 . Registered on 17 May 2012.

Dataset Information

Chain-Shortened Myostatin Inhibitory Peptides Improve Grip Strength in Mice.

Publications

Chain-Shortened Myostatin Inhibitory Peptides Improve Grip Strength in Mice.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets