Oxygen-sensitive MRI assessment of tumor response to hypoxic gas breathing challenge.

ABSTRACT: Oxygen-sensitive MRI has been extensively used to investigate tumor oxygenation based on the response (R₂ * and/or R₁ ) to a gas breathing challenge. Most studies have reported response to hyperoxic gas indicating potential biomarkers of hypoxia. Few studies have examined hypoxic gas breathing and we have now evaluated acute dynamic changes in rat breast tumors. Rats bearing syngeneic subcutaneous (n = 15) or orthotopic (n = 7) 13762NF breast tumors were exposed to a 16% O₂ gas breathing challenge and monitored using blood oxygen level dependent (BOLD) R₂ * and tissue oxygen level dependent (TOLD) T₁ -weighted measurements at 4.7 T. As a control, we used a traditional hyperoxic gas breathing challenge with 100% O₂ on a subse

SUBMITTER: Yang DM 

PROVIDER: S-EPMC6581571 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature