Ontology highlight
ABSTRACT:
SUBMITTER: Wei R
PROVIDER: S-EPMC6581654 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wei Rui R Gu Liangbiao L Yang Jin J Yang Kun K Liu Junling J Le Yunyi Y Lang Shan S Wang Haining H Thai Dung D Yan Hai H Hong Tianpei T
iScience 20190530
Under extreme conditions or by genetic modification, pancreatic α-cells can regenerate and be converted into β-cells. This regeneration holds substantial promise for cell replacement therapy in diabetic patients. The discovery of clinical therapeutic strategies to promote β-cell regeneration is crucial for translating these findings into clinical applications. In this study, we reported that treatment with REMD 2.59, a human glucagon receptor (GCGR) monoclonal antibody (mAb), lowered blood gluco ...[more]