Ontology highlight
ABSTRACT:
SUBMITTER: Muller KH
PROVIDER: S-EPMC6581741 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cell reports 20190601 11
Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell biological processes that lead to mineral nucleation remains elusive. Here, we report that biomineralization of bone and the vasculature is associated with extracellular poly(ADP-ribose) synthesized by poly(ADP-ribose) polymerases in response to oxidative and/o ...[more]