Ontology highlight
ABSTRACT:
SUBMITTER: Gil-Ranedo J
PROVIDER: S-EPMC6581792 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Gil-Ranedo Jon J Gonzaga Eleanor E Jaworek Karolina J KJ Berger Christian C Bossing Torsten T Barros Claudia S CS
Cell reports 20190601 10
Adult stem cells reactivate from quiescence to maintain tissue homeostasis and in response to injury. How the underlying regulatory signals are integrated is largely unknown. Drosophila neural stem cells (NSCs) also leave quiescence to generate adult neurons and glia, a process that is dependent on Hippo signaling inhibition and activation of the insulin-like receptor (InR)/PI3K/Akt cascade. We performed a transcriptome analysis of individual quiescent and reactivating NSCs harvested directly fr ...[more]