CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
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ABSTRACT:
SUBMITTER: Briant LJB
PROVIDER: S-EPMC6581793 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
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CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.
Briant Linford J B LJB Dodd Michael S MS Chibalina Margarita V MV Rorsman Nils J G NJG Johnson Paul R V PRV Carmeliet Peter P Rorsman Patrik P Knudsen Jakob G JG
Cell reports 20180601 11
Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrate. Here, we show that glucagon secretion in low glucose conditions is maintained by fatty acid metabolism in both mouse and human islets, and that inhibiting this metabolic pathway profoundly decrease ...[more]
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