Ontology highlight
ABSTRACT:
SUBMITTER: Cianciaruso C
PROVIDER: S-EPMC6581796 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Cell reports 20190601 10
Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the enrichment, quantification, and proteomic and lipidomic analysis of EVs released from mouse TAMs (TAM-EVs). Compared to source TAMs, TAM-EVs present molecular profiles associated with a Th1/M1 polarization signature, enhanced inflammation and immune r ...[more]