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Serum miR-17 levels are downregulated in obese, African American women with elevated HbA1c.


ABSTRACT: Purpose:Type 2 diabetes is heterogeneous disease characterized by several conditions including hyperglycemia. It is estimated that over 350 million people worldwide are suffering from type 2 diabetes and this number is expected to rise. According to the CDC, African Americans were observed to have a 40% higher incidence of diabetes compared to European Americans. Epigenetic modulating mechanisms such as microRNAs (miRNAs), have recently been established as a massive regulatory machine in metabolic syndrome, obesity and type 2 diabetes. In the present study, we aimed to investigate the serum levels of circulating miRNA 17 (miR-17) of obese, African American women with elevated HbA1c. Methods:We investigated miR-17 serum levels using qPCR. Then we used Pairwise Pearson Correlation Test to determine the relationship between clinical metabolic parameters and miR-17 serum levels. Results:The results indicated that participants with elevated HbA1c exhibited a down regulation of serum miR-17 levels compared to participants with normal HbA1c. MiR-17 was also correlated with serum calcium in participants with normal HbA1c. Conclusions:The results suggest that serum miR-17 is involved in the regulation of glucose and calcium homeostasis, which may contribute to the development of type 2 diabetes.

SUBMITTER: Williams A 

PROVIDER: S-EPMC6582114 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Serum miR-17 levels are downregulated in obese, African American women with elevated HbA1c.

Williams Ariel A   Dougal Dara Mc DM   Jenkins Willysha W   Greene Natasha N   Williams-DeVane Clarlynda C   Kimbro K Sean KS  

Journal of diabetes and metabolic disorders 20190509 1


<h4>Purpose</h4>Type 2 diabetes is heterogeneous disease characterized by several conditions including hyperglycemia. It is estimated that over 350 million people worldwide are suffering from type 2 diabetes and this number is expected to rise. According to the CDC, African Americans were observed to have a 40% higher incidence of diabetes compared to European Americans. Epigenetic modulating mechanisms such as microRNAs (miRNAs), have recently been established as a massive regulatory machine in  ...[more]

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