Ontology highlight
ABSTRACT:
SUBMITTER: Rivas MP
PROVIDER: S-EPMC6582250 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Rivas Maria Prates MP Aguiar Talita Ferreira Marques TFM Fernandes Gustavo Ribeiro GR Caires-Júnior Luiz Carlos LC Goulart Ernesto E Telles-Silva Kayque Alves KA Cypriano Monica M de Toledo Silvia Regina Caminada SRC Rosenberg Carla C Carraro Dirce Maria DM da Costa Cecilia Maria Lima CML da Cunha Isabela Werneck IW Krepischi Ana Cristina Victorino ACV
Frontiers in genetics 20190612
Hepatoblastoma is an embryonal liver tumor carrying few genetic alterations. We previously disclosed in hepatoblastomas a genome-wide methylation dysfunction, characterized by hypermethylation at specific CpG islands, in addition to a low-level hypomethylation pattern in non-repetitive intergenic sequences, in comparison to non-tumoral liver tissues, shedding light into a crucial role for epigenetic dysregulation in this type of cancer. To explore the underlying mechanisms possibly related to ab ...[more]