Dataset Information

Lipoprotein particle concentration measured by nuclear magnetic resonance spectroscopy is associated with gestational age at delivery: a prospective cohort study.

ABSTRACT:

Objective

To estimate the association between lipoprotein particle concentrations in pregnancy and gestational age at delivery.

Design

Prospective cohort study.

Setting

The study was conducted in the USA at the University of North Carolina.

Population

We assessed 715 women enrolled in the Pregnancy, Infection, and Nutrition study from 2001 to 2005.

Methods

Fasting blood was collected at two time points (<20 and 24-29 weeks of gestation). Nuclear magnetic resonance (NMR) quantified lipoprotein particle concentrations [low-density lipoprotein (LDL), high-density lipoprotein (HDL), very-low density lipoprotein (VLDL)] and 10 subclasses of lipoproteins. Concentrations were assessed as continuous measures, with the exception of medium HDL which was classified as any or no detectable level, given its distribution. Cox proportional hazards models estimated hazard ratios (HR) for gestational age at delivery adjusting for covariates.

Main outcome measures

Gestational age at delivery, preterm birth (<37 weeks of gestation), and spontaneous preterm birth.

Results

At <20 weeks of gestation, three lipoproteins were associated with later gestational ages at delivery [large LDL_NMR (HR 0.78, 95% CI 0.64-0.96), total VLDL_NMR (HR 0.77, 95% CI 0.61-0.98), and small VLDL_NMR (HR 0.78, 95% CI 0.62-0.98], whereas large VLDL_NMR (HR 1.19, 95% CI 1.01-1.41) was associated with a greater hazard of earlier delivery. At 24-28 weeks of gestation, average VLDL_NMR (HR 1.25, 95% CI 1.03-1.51) and a detectable level of medium HDL_NMR (HR 1.90, 95% CI 1.19-3.02) were associated with earlier gestational ages at delivery.

Conclusion

In this sample of pregnant women, particle concentrations of VLDL_NMR , LDL_NMR , IDL_NMR , and HDL_NMR were each independently associated with gestational age at delivery for all deliveries or spontaneous deliveries <37 weeks of gestation. These findings may help formulate hypotheses for future studies of the complex relationship between maternal lipoproteins and preterm birth.

Tweetable abstract

Nuclear magnetic resonance spectroscopy may identify lipoprotein particles associated with preterm delivery.

SUBMITTER: Grace MR

PROVIDER: S-EPMC6582364 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Publications

Lipoprotein particle concentration measured by nuclear magnetic resonance spectroscopy is associated with gestational age at delivery: a prospective cohort study.

Grace M R MR Vladutiu C J CJ Nethery R C RC Siega-Riz A M AM Manuck T A TA Herring A H AH Savitz D D Thorp J T JT

BJOG : an international journal of obstetrics and gynaecology 20171016 7

<h4>Objective</h4>To estimate the association between lipoprotein particle concentrations in pregnancy and gestational age at delivery.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>The study was conducted in the USA at the University of North Carolina.<h4>Population</h4>We assessed 715 women enrolled in the Pregnancy, Infection, and Nutrition study from 2001 to 2005.<h4>Methods</h4>Fasting blood was collected at two time points (<20 and 24-29 weeks of gestation). Nuclear magnetic reson ...[more]

PMID: 28886230

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Project description:BackgroundRemnant cholesterol (RC) can partly explain the residual risk in atherosclerotic cardiovascular disease (ASCVD). A consensus method of measuring RC levels has not been established yet. In clinical practice, RC levels are usually calculated from the standard lipid profile, which are not true RC. Nuclear magnetic resonance (NMR) can measure RC levels directly. This study aimed to characterize RC at fasting and non-fasting states in more details and establish the performance of calculated RC and NMR-measured RC.MethodsBlood samples at fasting state and at 2 h and 4 h postprandial states were collected in 98 subjects. Lipid parameters including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), subfractions 3, 4, and 5 of very low-density lipoprotein cholesterol (VLDL3-C, VLDL4-C, and VLDL5-C, respectively), and intermediate-density lipoprotein cholesterol (IDL-C) were measured by enzymatic method and NMR. RC levels calculated from the standard lipid profile or measured by NMR were referred here as RCe or RCn.ResultsThe RCe and RCn levels were different, but both of them increased after a meal (P < 0.05), especially at 4 h postprandial state. Low correlations were found between RCe and RCn in the 1st, 2nd, and 3rd quartiles of TG, but RCn showed great correlation with RCe in the highest quartile regardless of the fasting or non-fasting state (R = 0.611, 0.536, and 0.535 for 0 h, 2 h, and 4 h, respectively). However, across the 2nd and 3rd quartiles, RCe levels were nearly close to RCn levels. RCe levels tended to overestimate RCn levels in the 1st quartile of TGe levels with median differences of 0.23(- 0.13, 0.63) and underestimate RCn levels with median differences of - 0.23(- 0.33, 0.07) in the highest quartile of TGe levels.ConclusionsRC calculated from the standard lipid profile as TC minus LDL-C minus HDL-C is different from the NMR-measured RC. According to different TG levels, RC could overestimate or underestimate the actual RC level. Developing a consensus clinical method to measure RC levels is necessary, so that results from different studies and platforms can be more directly compared.Trial registrationChinese Clinical Trial Registry, ChiCTR1900020873. Registered in 21 January 2019 - Retrospectively registered.

Dataset Information

Lipoprotein particle concentration measured by nuclear magnetic resonance spectroscopy is associated with gestational age at delivery: a prospective cohort study.

Objective

Design

Setting

Population

Methods

Main outcome measures

Results

Conclusion

Tweetable abstract

Publications

Lipoprotein particle concentration measured by nuclear magnetic resonance spectroscopy is associated with gestational age at delivery: a prospective cohort study.

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