Ontology highlight
ABSTRACT:
SUBMITTER: Owen DH
PROVIDER: S-EPMC6582566 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Owen Dwight H DH Giffin Michael J MJ Bailis Julie M JM Smit Marie-Anne Damiette MD Carbone David P DP He Kai K
Journal of hematology & oncology 20190618 1
Small cell lung cancer (SCLC) accounts for approximately 15% of all lung cancers. Despite high rates of response to first-line chemotherapy and radiotherapy, patients with extensive-stage disease eventually relapse, and very few patients survive more than 5 years from diagnosis. Treatment options for recurrent or refractory disease are limited, and the treatments that do exist are associated with significant treatment-related toxicities. Delta-like ligand 3 (DLL3) is an inhibitory Notch ligand t ...[more]