Dataset Information
Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status.
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ABSTRACT: Background
CIC-mutant oligodendroglial tumours linked to better prognosis. We aim to investigate associations between CIC gene mutation status, MR characteristics and clinical features.Methods
Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive (TCGA/TCIA) for 59 patients with oligodendroglial tumours were used. Differences between CIC mutation and CIC wild-type were tested using Chi-square test and binary logistic regression analysis.Results
In univariate analysis, the clinical variables and MR features, which consisted 3 selected features (subventricular zone[SVZ] involvement, volume and seizure history) were associated with CIC mutation status (all p?ConclusionsAbsence of seizure history and SVZ involvement (-) was associated with a higher incidence of CIC mutation.
SUBMITTER: Liu Z
PROVIDER: S-EPMC6582578 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Oligodendroglial tumours: subventricular zone involvement and seizure history are associated with CIC mutation status.
BMC neurology 20190618 1
<h4>Background</h4>CIC-mutant oligodendroglial tumours linked to better prognosis. We aim to investigate associations between CIC gene mutation status, MR characteristics and clinical features.<h4>Methods</h4>Imaging and genomic data from the Cancer Genome Atlas and the Cancer Imaging Archive (TCGA/TCIA) for 59 patients with oligodendroglial tumours were used. Differences between CIC mutation and CIC wild-type were tested using Chi-square test and binary logistic regression analysis.<h4>Results< ...[more]