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FAM83H is involved in stabilization of ?-catenin and progression of osteosarcomas.

ABSTRACT: BACKGROUND:FAM83H was initially identified as a protein essential for dental enamel formation. Recent reports have shown that FAM83H is also involved in the progression of human cancers in conjunction with tumor-associated molecules, such as MYC and ?-catenin. However, the role of FAM83H in sarcoma has not yet been investigated. METHODS:The expression and roles of FAM83H and ?-catenin were evaluated in human osteosarcomas from 34 patients and osteosarcoma cells. RESULTS:The expression of nuclear FAM83H, cytoplasmic FAM83H, and ?-catenin were significantly associated with each other and significantly associated with shorter survival of osteosarcoma patients by univariate analysis. In multivariate analysis, cytoplasmic expression of FAM83H was an independent indicator of shorter survival of osteosarcoma patients (overall survival; P?

SUBMITTER: Kim KM 

PROVIDER: S-EPMC6582611 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas.

Kim Kyoung Min KM   Hussein Usama Khamis UK   Park See-Hyoung SH   Kang Mi Ae MA   Moon Young Jae YJ   Zhang Zhongkai Z   Song Yiping Y   Park Ho Sung HS   Bae Jun Sang JS   Park Byung-Hyun BH   Ha Sang Hoon SH   Moon Woo Sung WS   Kim Jung Ryul JR   Jang Kyu Yun KY  

Journal of experimental & clinical cancer research : CR 20190618 1

<h4>Background</h4>FAM83H was initially identified as a protein essential for dental enamel formation. Recent reports have shown that FAM83H is also involved in the progression of human cancers in conjunction with tumor-associated molecules, such as MYC and β-catenin. However, the role of FAM83H in sarcoma has not yet been investigated.<h4>Methods</h4>The expression and roles of FAM83H and β-catenin were evaluated in human osteosarcomas from 34 patients and osteosarcoma cells.<h4>Results</h4>The  ...[more]

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